Journal article
The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): a randomised, double-blind, placebo-controlled, multicentre clinical trial
CG Davey, AM Chanen, SE Hetrick, SM Cotton, A Ratheesh, GP Amminger, J Koutsogiannis, M Phelan, E Mullen, BJ Harrison, S Rice, AG Parker, OM Dean, A Weller, M Kerr, AL Quinn, L Catania, N Kazantzis, PD McGorry, M Berk
Lancet Psychiatry | ELSEVIER SCI LTD | Published : 2019
Abstract
Background: Medication is commonly used to treat youth depression, but whether medication should be added to cognitive behavioural therapy (CBT) as first-line treatment is unclear. We aimed to examine whether combined treatment with CBT and fluoxetine was more effective than CBT and placebo in youth with moderate-to-severe major depressive disorder. Methods: The Youth Depression Alleviation–Combined Treatment (YoDA-C) trial was a randomised, double-blind, placebo-controlled, multicentre clinical trial. Participants were aged 15–25 years with moderate-to-severe MDD and had sought care at one of four clinical centres in metropolitan Melbourne, Australia. Patients were randomly assigned (1:1) t..
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Grants
Awarded by Brain and Behavior Research Foundation
Funding Acknowledgements
Australian National Health and Medical Research Council.